DKM活性分子 Dynamic Key Med 活性化合物活性分子平台 7*24在线

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PD-1/PD-L1

Angiogenesis

Apoptosis

Natural product

Cancer

Epigenetics

Stem Cells

ADC Related

DKM活性化合物

Ganetespib作为HSP90抑制剂，在多种血液系统恶性肿瘤及实体瘤细胞系中均表现出强效的细胞杀伤活性。其通过靶向抑制缺氧诱导因子-1α（HIF-1α）和信号转导与转录激活因子3（STAT3），在结直肠癌中发挥显著抗血管生成效应。

Ganetespib是HSP90抑制剂，对多种血液及实体肿瘤具细胞毒性，通过抑制HIF-1α和STAT3发挥结直肠癌抗血管生成作用。

DKM活性化合物 14小时前

232

DKM活性化合物

TMZ（替莫唑胺）是一种单功能SN-1烷化剂，特异性攻击DNA碱基中环内氮原子与环外氧原子。在生理pH环境下，TMZ通过非酶促水解转化为高反应性中间体MTIC，并迅速裂解为甲基重氮鎓阳离子；后者作为强效甲基化试剂，共价结合DNA，阻断复制起始，激活DNA损伤应答通路，最终驱动肿瘤细胞走向凋亡——由此可见，TMZ本质上属于一类以DNA为直接靶标、依赖损伤触发机制发挥抗肿瘤效应的前药。

替莫唑胺（TMZ）是一种口服DNA烷基化剂，可穿透血脑屏障，代谢为MTIC诱导DNA甲基化损伤，用于治疗恶性胶质瘤等肿瘤。

DKM活性化合物 1天前

206

DKM活性化合物

Daraxonrasib (RMC-6236) / RAS-IN-2 (RMC6236)：基于理性药物设计的RAS靶向策略及其临床转化前景

RAS基因突变驱动多种癌症，靶向RAS(ON)长期受限。Daraxonrasib通过结合CypA与RAS(ON)形成三元复合物，阻断下游信号，实现广谱抑制，是RAS靶向治疗的重大突破。

DKM活性化合物 4天前

15030

DKM活性化合物

现货供应，高纯度苯乙酰辅酶A（Phenylacetyl CoA），CAS 7532-39-0：抗生素生物合成与环境污染物靶向降解的关键代谢枢纽；依托CRISPR精准编辑与理性酶工程，其工业化稳定性与功能可塑性大幅提升，正快速支撑新药创制、生态修复与低碳农业三大战略方向。

苯乙酰辅酶A为高纯度现货，参与关键合成代谢，广泛用于生化研究及药物开发。

DKM活性化合物 4天前

12537

DKM活性化合物

Calyculin A（花萼海绵体诱癌素A）：一种高效、细胞膜穿透性强的PP1/PP2A双靶向抑制剂，IC₅₀ 低至0.5–1 nM。

Calyculin A花萼海绵体诱癌素A是强效PP1/PP2A抑制剂，IC50达0.5–2 nM，具细胞渗透性，广泛用于信号转导与癌症研究，并显示正性肌力及调控TNF-α等作用。

DKM活性化合物 4天前

4910

DKM活性化合物

Sotorasib：首款靶向KRAS突变药物的诞生之路——从科学突破到临床落地的完整历程

2021年5月29日，FDA加速批准全球首款KRASG12C抑制剂Lumakras，用于经治晚期非小细胞肺癌患者。该药靶向KRAS-G12C突变，显著改善难治性肺癌治疗格局。

DKM活性化合物 5天前

3244

DKM资讯

全部

PI3K/Akt/mTOR
- Akt
- AMPK
- ATM/ATR
- PI3K
- PDK
- FOXO
- MELK
- mTOR
- GSK-3
- PDK-1
- PI4K
- PIKfyve
- PIN1
- PTEN
- RSK
Epigenetics
- AMPK
- Aurora Kinase
- DNA Methyltransferase/DNA甲基转移酶
- Epigenetic Reader Domain/表观遗传阅读框
- FTO
- HDAC/组蛋白去乙酰化酶
- HES
- HIF
- Histone Acetyltransferase/组蛋白乙酰转移酶
- Histone Demethylase/组蛋白甲基转移酶
- Histone Methyltransferase/组蛋白甲基转移酶
- JAK
- MBD-containing protein
- METTL3
- MicroRNA/微RNA
- PAD
- PARP
- Pim
- PKC
- PRMT
- SF3B1
- Sirtuin
- TET
Methylation/甲基化
- PRMT
- EZH2
- DNA Methyltransferase
- LSD1
- MLL
- G9a/GLP
- JMJD
- NSD
- FTO
- SETD
- DOT1
- MAT2A
- SMYD
- COMT
- WDR5
- NNMT
- HNMT
- SAM MTase
- PPMTase
Immunology & Inflammation/免疫炎症
- AIM2
- AP-1
- Arginase/精氨酸酶
- Calcineurin
- CCR
- CD19
- CD2
- CD20
- CD22
- CD276/B7-H3
- CD28
- CD28-B7
- CD3
- CD38
- CD47
- CD6
- CD73
- CD74
- CD80
- cGAS
- Complement C3
- Complement Receptor
- Complement System/补体系统
- COX/环氧化酶
- CRTH2
- CTLA-4
- CXCR
- Cyclophilin
- FAP
- FKBP
- FLAP
- FPR
- Galectin/半乳糖凝集素
- Glucocorticoid Receptor/糖皮质激素受体
- Glycoprotein VI
- GM-CSF
- Histamine Receptor/组胺受体
- HMGB
- IFNAR/干扰素受体
- IKZF Family
- IL Receptor
- others
- IRAK
- IRF3
- LAG-3
- LanC-like protein
- Legumain
- LTA4H
- LTR
- MALT1
- Mesothelin
- MIF
- Mucin
- MyD88
- NADPH Oxidase/NADPH氧化酶
- NFAT
- NLR
- NO Synthesis
- NOS
- NOT
- Nrf2
- PD-1/PD-L1
- PG Synthase
- PSMA
- Pyroptosis/焦亡
- ROS
- S100A9
- Scavenger receptor
- SIK
- SOD
- SphK
- STING
- TENT
- Thrombopoietin Receptor/血小板生成素受体
- Tim3
- TLR
- TSPO
- VISTA
- XBP1
Protein Tyrosine Kinase/PTK酪氨酸蛋白激酶
- EGFR
- VEGFR
- PDGFR
- FGFR
- FLT3
- c-Kit
- Src
- c-Met
- Bcr-Abl
- BTK
- MEK
- HER2
- ALK
- IGF-1R
- CSF-1R
- Trk receptor
- Syk
- c-RET
- FAK
- Axl
- Mertk
- DYRK
- ROS1
- Tyro3
- Pyk2
- RON
- Ephrin receptor
- DDR
- Tie-2
- ACK
- Insulin Receptor
- Fer kinase
Angiogenesis
- EGFR
- VEGFR
- JAK
- PDGFR
- FGFR
- Src
- FLT
- FLT3
- HER2
- HIF
- Bcr-Abl
- BTK
- ALK
- Syk
- FAK
- Hck
- VDA
- ANGPTL
Apoptosis/凋亡
- Apoptosis related/凋亡相关
- Ras
- STAT
- TNF-alpha
- Bcl-2
- Caspase
- K-Ras
- Ferroptosis
- p53
- RIP kinase
- c-RET
- MDM
- MRP
- Antifolate
- Myc
- IAP
- OXPHOS
- PD-1/PD-L1
- FKBP
- PERK
- ABC Transporter
- Thymidylate Synthase
- Heme Oxygenase
- Photosensitizer
- Pyroptosis
- Annexin A
- Survivin
- Disulfidptosis
- ASK
- PFKFB
- DAPK
- Cuproptosis
- Nur77
- Bcl-6
- PKD
- NEDD8
- Necroptosis
- TACE
- FDX1
- Fas/FasL
- cytohesin
- TRADD
- SMARCA2
- ADAM10
Autophagy/自噬
- Autophagy
- Mitophagy
- Nrf2
- CXCR
- LRRK2
- ULK
- FKBP
- Heme Oxygenase
- cGAS
- Cell wall
- LC3
- GluCls
- OGA
- Beclin
- ATTECs
ER stress & UPR/内质网应激&UPR响应
- Antioxidant
- ROS
- HSP
- JNK
- eIF
- PERK
- IRE1
- ASK
- PKR
- PDI
- ER stress
- ATF-6
JAK/STAT
- EGFR
- STAT
- Pim
- JAK1
- JAK2
- JAK3
- Tyk2
MAPK
- Ras
- ERK
- p38 MAPK
- K-Ras
- Raf
- JNK
- MEK
- S6 Kinase
- MAP4K
- Mixed Lineage Kinase
- TAK1
- MAPKAPK2
- ASK
- MNK
- TOPK
- KLF
- p53
Cytoskeletal Signaling细胞骨架
- Akt
- Microtubule Associated
- Wnt/beta-catenin
- PKC
- HSP
- Bcr-Abl
- Integrin
- FAK
- ROCK
- Kinesin
- PAK
- Actin
- MLCK
- Dynamin
- MPS1
- PORCN
- KSP
- Gap-Junction
- Cardiac Myosin
- TACC3
- Piezo Channel
- Myosin
- Tight Junction Protein
Cell Cycle细胞周期
- DNA/RNA Synthesis
- CDK
- Ras
- Microtubule Associated
- K-Ras
- HSP
- Aurora Kinase
- Casein Kinase
- Serine/threonin kinase
- Rho
- ROCK
- Chk
- Kinesin
- PLK
- Myc
- DHFR
- eIF
- PD-1/PD-L1
- PAK
- PERK
- DYRK
- AP-1
- MPS1
- p21
- Wee1
- RUNX
- LIM kinase
- BMI-1
- PP2A
- Nur77
- PFKFB
- TOPK
- Cell Cycle Arrest
- Haspin Kinase
- DOCK
- TACC3
- CDK4/6
- APC
- FOXM1
- Cyclin
- Choline kinase
- Mad2
- KRas inhibitor
TGF-beta/Smad
- PKC
- TGF-beta/Smad
- Bcr-Abl
- ROCK
DNA Damage/DNA Repair/DNA损伤/修复
- DNA/RNA Synthesis
- HDAC
- Topoisomerase
- PPAR
- PARP
- Sirtuin
- Casein Kinase
- ATM/ATR
- MDM
- DNA-PK
- DNA alkylator
- DHFR
- Nucleoside Analog/Antimetabolite
- eIF
- Telomerase
- CRISPR/Cas9
- Thymidylate Synthase
- RAD51
- Alkylating Agent
- RNR
- NUDIX
- BMI-1
- LIM kinase
- OGG1
- MTH1
- G-quadruplex
- High-mobility Group
- FENs
- SMN
- Pax
- WRN
Stem Cells & Wnt/干细胞&Wnt通路
- JAK
- STAT
- ERK
- Wnt/beta-catenin
- TGF-beta/Smad
- GSK-3
- Casein Kinase
- ROCK
- Hedgehog/Smoothened
- PKA
- Notch
- Secretase
- PORCN
- OCT
- KLF
- Fascin
- Stemness kinase
- SFRP
Hippo
- TEAD
- YAP
- MAP4K
- LATS
- MST
Metabolism代谢
- 11β-HSD
- 15-PGDH
- 2OG Oxygenase
- 3-PGDH
- 3MST
- 6PGD
- ACAT
- ACC
- Acetolactate Synthase
- ACMSD
- Aconitate hydratase
- ACS
- Adenosine Deaminase/腺苷脱氨酶
- Adenosylhomocysteinase
- ADP-ribosyltransferase
- AhR
- AKR
- ALDH
- Aldose Reductase/醛糖还原酶
- Aminopeptidase/氨肽酶
- Antifolate/抗叶酸
- AO
- ApoE
- Arginase/精氨酸酶
- Asparagine synthetase
- ATF/CREB proteins
- ATP Citrate Lyase/ATP柠檬酸裂解酶
- BBOX
- BDK
- Beta-glucuronidase
- Carbonic Anhydrase/碳酸酐酶
- Carboxylesterase
- Carboxypeptidase/羧肽酶
- Cardiolipin Peroxidase
- Cathepsin/组织蛋白酶
- Ceramidase/神经酰胺酶
- CETP
- Cholesterol Transporter
- CPA
- CPSI
- Creatine kinase
- Cryptochrome
- CSE
- CYP51
- Cytochrome c oxidase
- D-amino acid oxidase
- D6D
- DAPA synthase
- Decarboxylase/脱羧酶
- Dehydrogenase/脱氢酶
- DGAT
- DGK
- Dopamine β-hydroxylase
- E-NTPDase
- Elastase/弹性蛋白酶
- Enolase/烯醇化酶
- Enteropeptidase
- ERAP
- FABP
- Factor Xa
- Farnesyl Transferase/法尼基转移酶
- FAS
- FBPase/二磷酸酶
- Ferroptosis/铁死亡
- FOXO
- FTO
- Fumarate hydratase
- FVII
- FXR
- G0/G1 switch protein 2
- Galactosidases
- GCN
- GCS
- GGTase
- Glucokinase/葡萄糖激酶
- Glucosidase/葡萄糖苷酶
- GLUT
- Glutaminase C
- Glutathione Reductase
- GOAT
- Glyoxalase
- GPx
- GSNOR
- GST
- Heme Oxygenase (HO)
- Hexokinase/己糖激酶
- HMGCR
- HPSE
- Hydrolase/水解酶
- Hydroxylase/羟化酶
- IDH
- IDO
- Ketohexokinase
- LDL
- LDLR
- Lipase/脂肪酶
- Lipoxygenase/脂氧合酶
- LOX
- LRH-1
- LXR
- MAGL
- MASTL
- MDH
- MetAP
- MGAT
- Mineralocorticoid Receptor/盐皮质激素受体
- Mitochondrial Electron Transport Chain
- Mitochondrial Metabolism/线粒体代谢
- MPC
- NAMPT
- Neprilysin/脑啡肽酶
- NNMT
- NPP
- NPR
- NQO
- OGT
- OPA1
- P448
- P450
- PAI-1
- PARG
- PDE
- PDHK
- PEPCK
- PGAM1
- PGC-1α
- PHGDH
- Phospholipase/磷脂酶
- PI5P4K
- PKM1
- PKM2
- Procollagen C Proteinase
- Proprotein convertases
- Pyruvate Kinase/丙酮酸激酶
- QR
- RAR/RXR
- RBP
- REV-ERB
- ROR
- SCD
- sEH
- SGK
- Sialyltransferase
- SHMT
- SLC25
- Sphingosine acyltransferase
- SQOR
- Srx
- Steroid Sulfatase
- TDO
- TGH
- Thioredoxin/硫氧还蛋白
- Thrombin凝血酶
- Transferase
- Transketolase/转酮酶
- TrxR
- Trypanothione reductase
- UGT
- VD/VDR
- Xanthine Oxidase/黄嘌呤氧化酶
- αKGD
Ubiquitin泛素化
- E3 Ligase
- DUB
- Proteasome
- E1 Activating
- p97
- SUMO
- E2 conjugating
Neuronal Signaling/神经信号
- 5-HT Receptor | 5-羟色胺受体
- AAK1
- AChE
- AChR
- Adenosine Kinase | 腺苷激酶
- Adrenergic Receptor | 肾上腺素能受体
- AMPAR
- Amyloid-β | 淀粉样蛋白-β
- Calcium Channel
- CaMK
- Cannabinoid Receptor | 大麻素受体
- CGRP Receptor | 降钙素基因相关肽受体
- Cholecystokinin Receptor | 缩胆囊素受体
- Cholinesterase
- CHT
- COMT
- DAT
- Dopamine Receptor | 多巴胺受体
- Endorphin
- Enkephalinase
- FAAH
- GABA Receptor | GABA受体
- GABA transporter
- Glucosylceramide Synthase | 葡萄糖神经酰胺合成酶
- GluR
- Glutamate Release
- GPR119
- GPR139
- GPR24
- GPR55
- Histamine Receptor | 组胺受体
- Huntingtin
- Imidazoline Receptor
- Kainate receptor
- MAO
- Melanocortin Receptor | 黑素皮质素受体
- mGluR
- MT Receptor
- NET
- Neuropeptide Y Receptor | 神经肽Y受体
- Neurotensin Receptor | 神经降压素受体
- NGF
- NK Receptor
- NMDA
- NMDAR
- Notch
- Nurr1
- OLIG2
- Opioid Receptor | 阿片受体
- OX Receptor
- P2X Receptor | P2X受体
- PSD-95
- QC
- RAGE
- REST
- Ryanodine Receptor-1
- S100β
- Secretase
- SERT
- Sigma Receptor
- SMS
- SSRIs
- Substance P
- TAAR
- Tau Protein | Tau蛋白
- TLX
- Trk Receptor | Trk受体
- TRP Channel | TRP通道
- TTR
- α-synuclein | α-突触核蛋白
- COX
NF-κB信号通路
- IKK
- MALT1
- NF-κB
- Nrf2
- Pirin
- RANKL
- RANKL/RANK
- RIP kinase | RIP激酶
- TAK1
GPCR & G蛋白
- Adrenergic Receptor
- AChR
- 5-HT Receptor
- Histamine Receptor
- Dopamine Receptor
- Ras
- K-Ras
- GPR
- Prostaglandin Receptor
- GluR
- Adenosine Receptor
- P2 Receptor
- CXCR
- CCR
- Angiotensin Receptor
- S1P Receptor
- Hedgehog/Smoothened
- Cannabinoid Receptor
- PKA
- SGLT
- Opioid Receptor
- cAMP
- Glucagon Receptor
- Sigma Receptor
- PAR
- Endothelin Receptor
- Neurokinin Receptor
- LTR
- LPA Receptor
- PKG
- Guanylate Cyclase
- OX Receptor
- GPCR19
- Platelet aggregation
- GTPase
- Vasopressin Receptor
- CGRP Receptor
- FPR
- Adenylyl Cyclase
- CCK receptor
- MT Receptor
- AdipoR
- PKD
- Taste Receptor
- NPY receptor
- Melanocortin Receptor
- Apelin receptor
- GLP-1 Receptor
- GHSR
- Oxytocin Receptor
- GRK
- CaSR
- Bradykinin Receptor
- Arrestin
- Leukotriene
- DOCK
- Imidazoline Receptor
- TSH Receptor
- TAAR
- Orphan Receptor
- GNRH Receptor
- MCHR
- PAFR
- CRFR
- RXFP receptor
- RGS
Endocrinology & Hormones/内分泌&激素
- 5-alpha Reductase | 5-alpha还原酶
- ACE
- Adrenergic Receptor | 肾上腺素能受体
- Androgen Receptor | 雄激素受体
- Aromatase | 芳香酶
- ERR
- GHSR
- Glucocorticoid Receptor | 糖皮质激素受体
- GNRH Receptor | GNRH受体
- Mineralocorticoid Receptor | 盐皮质激素受体
- Opioid Receptor | 阿片受体
- Progesterone Receptor | 孕酮受体
- PTGR
- PTHR
- Renin
- Sepiapterin reductase
- SSTR
- Taste receptor
- Thyroid Hormone Receptor | 甲状腺激素受体
- TPO
- TRHR
- TSH Receptor | 促甲状腺激素受体
Transmembrane Transporters/跨膜转运
- ABC Transporter
- AKK1
- ANT
- AQP
- AQP3
- ARF
- ATP Synthase | ATP合成酶
- ATPase
- BCRP
- Calcium Channel 钙离子通道
- CFTR
- Chloride Channel | 氯离子通道
- CRAC Channel | CRAC通道
- CRM1
- EAAT
- Efflux pump
- ENT
- Ferroportin
- GABA Receptor | GABA受体
- GLUT
- Glutamate transporter
- Glycine transporter
- HCN Channel | HCN通道
- IBAT
- MAT
- MCT
- Na+/Ca2+ Exchanger
- Na+/K+ ATPase
- Na/HCO3 cotransporter
- NKCC
- Oct
- OCTN
- Organic Anion Transporter
- P-gp
- P2X Receptor | P2X受体
- Piezo
- Potassium Channel | 钾通道
- Proton Pump | 质子泵
- SEO1
- SGLT
- SLC
- Sodium Channel | 钠通道
- SV2
- TRP Channel | TRP通道
- UCP
- URAT1
- Urea Transporter
- VDAC
- VRAC
Proteases蛋白酶
- HDAC
- Caspase
- MMP
- HCV Protease
- Cysteine Protease
- HIV Protease
- Tyrosinase
- DPP
- Proteasome
- Serine Protease
- Secretase
- Acyltransferase
- Glutaminase
- Thrombin
- Cathepsin B
- PCSK9
- Carboxypeptidase
- PREP
- PAD
- Neprilysin
- SGK
- MALT
- Aminopeptidase
- 3C-Like Protease
- GOT
- PSMA
- PGDS
Microbiology微生物
- Bacterial
- Antibiotics
- Anti-infection
- Fungal
- Antiviral
- COVID-19
- Parasite
- Reverse
- Transcriptase
- HIV
- HCV Protease
- HIV Protease
- ribosome
- SARS-CoV
- Influenza Virus
- β-lactamase
- Integrase
- HBV
- CMV
- HCV
- Neuraminidase
- HSV
- Thioredoxin Reductase
- Enterovirus
- RSV
- DprE1
- 3C-Like Protease
- Ribosomal Peptidyl Transferase
- HPV
Others
- Others
- Dyes
- Antineoplastic and Immunosuppressive Antibiotics
- ADC Cytotoxin
- Selection Antibiotics for Transfected Cell
- PROTAC
- Antibiotics for Mammalian Cell Culture
- ADC Linker
- Molecular Glues
- Antibiotics for Plant Cell Culture
- PROTAC Linker
- Hydrotropic Agents
- E3 ligase Ligand
- Target Protein Ligand
- Antibody-Drug Conjugate
- Drug-Linker Conjugates for ADC
- Chelating Agent
- Surfactant
- Enzyme Substrate

PI-540 CAS#885616-78-4 目录号D968443

￥10800.00

Ganetespib (STA-9090) HSP90抑制剂（CAS#888216-25-9 目录号D917655）

￥1225.00

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