Natamycin,纳他霉素(CAS#7681-93-8 目录号D912381) Fungal inhibitor Microbiology
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50mg | ¥ 485.00 | 100 | |
100mg | ¥ 775.00 | 100 | |
200mg | ¥ 1465.00 | 100 |
别名 | Pimaricin,Synogil,PIMAFUCIN,纳他霉素 |
产品名 | Natamycin |
CAS号 | 7681-93-8 |
目录号 | D912381 |
化学式 | C₃₃H₄₇NO₁₃ |
分子量 | 665.73 |
溶解度 | ≥ 16.425mg/mL in DMSO with gentle warming |
靶点 | Fungal inhibitor |
储存条件 | Store at -20°C |
用途 | 仅供科学研究使用!不能用于人体及动物治疗 |
纯度 | >99% |
靶点及简介 :
Antifungal macrolide polyene
Natamycin 特异性结合麦角固醇存在于模型膜上。Natamycin 在生长被阻止的条件下不改变酵母细胞膜的渗透性。[1] Natamycin 阻止分离的液泡的融合而不损害液泡膜的屏障功能。Natamycin 干扰了蜂窝液泡形态,造成在酵母细胞中的许多更小的液泡结构的形成。Natamycin 抑制了液泡融合的起动阶段。[2] Natamycin显示对暗色真菌,Curvularia种低的MIC。[3] Natamycin和γ-环糊精(NT-γ何秀兰的)形成复合物以增加NT在水溶液中的溶解度和稳定性,并降低了药物的副作用,而不会降低抗真菌活性。[4] Natamycin和Natamycin-gamma CyD 复合物的MIC90低于0.0313 毫克/毫升,这表明gamma CyD有效地提高Natamycin的抗真菌活性,从而表明了Natamycin-gamma CyD 复合物的临床应用价值。[5]
Natamycin is a naturally-occurring macrolide polyene antifungal agent produced during fermentation by the bacterium S. natalensis, commonly found in soil. With minimal inhibitory concentrations ranging from 4-64 μM, natamycin is used to treat fungal infections, including Candida, Aspergillus, Cephalosporium, Fusarium, and Penicillium.[1],[2],[3] Natamycin blocks fungal growth by binding specifically to ergosterol with an apparent affinity of ~100 μM, but it does not permeabilize cell membranes as other polyene antibiotics are known to do.[2] Natamycin is also used in the food industry as a preservative.[4]
Reference:
[1]. Lalitha, P., Vijaykumar, R., Prajna, N.V., et al. In vitro natamycin susceptibility of ocular isolates of Fusarium and Aspergillus species: Comparison of commercially formulated natamycin eye drops to pharmaceutical-grade powder. Journal of Clinical Microbiology 46(10), 3477-3478 (2008).
[2]. te Welscher, Y.M., ten Napel, H.H., Balagué, M.M., et al. Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane. The Journal of Biological Chemisty 283(10), 6393-6401 (2008).
[3]. Dong, X.H., Gao, W.J., and He, X.P. Antifungal efficacy of natamycin in experimental fusarium solani keratitis. Int.J.Ophthalmol. 5(2), 143-146 (2012).
[4]. de Vries, R.P., de Lange, E.S., Wösten, H.A.B., et al. Control and possible applications of a novel carrot-spoilage basidiomycete, Fibulorhizoctonia psychrophila. Antonie Van Leeuwenhoek 93, 407-413 (2008).
参考文献:
DMSO | 100 mg/mL (150.21 mM) |
Water | Insoluble |
Ethanol | Insoluble |
制备储备液
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
1 mM | 1.47 mL | 7.33 mL | 14.67 mL |
5 mM | 0.29 mL | 1.47 mL | 2.93 mL |
10 mM | 0.15 mL | 0.73 mL | 1.47 mL |
50 mM | 0.03 mL | 0.15 mL | 0.29 mL |
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