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| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5mg | ￥ 1184.00 | 100 | |
| 10mg | ￥ 1473.00 | 100 | |
| 50mg | ￥ 4433.00 | 100 |
| 别名 | AAE-581，巴利卡替 |
| 产品名 | Balicatib |
| CAS号 | 354813-19-7 |
| 目录号 | D800194 |
| 化学式 | C₂₃H₃₃N₅O₂ |
| 分子量 | 411.54 |
| 溶解度 | ≥ 17mg/mL in DMSO |
| 靶点 | Cathepsin K inhibitor |
| 储存条件 | Store at -20°C |
| 用途 | 仅供科学研究使用!不能用于人体及动物治疗 |
| 纯度 | >99% |
靶点及简介 ：Cathepsin K inhibitor
Balicatib是一种有效的、选择性的组织蛋白酶K抑制剂;在基于细胞的酶占用试验中比对组织蛋白酶B, L和S的作用强10-100倍。
| 分子量 | 411.54 | ||
|---|---|---|---|
| 化学式 | C23H33N5O2 | ||
| CAS号 | 354813-19-7 | ||
| 储存条件 | 3年 | -20°C | 粉状 |
| 1年 | -80°C | 溶于溶剂 | |
| 体外实验* | |
|---|---|
| 细胞系 | Hep G2 and SMMC-7721 cells |
| 方法 | Cell viability assay. The 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay was used to measure drug sensitivity. Briefly, Hep G2 and SMMC-7721 cells were seeded into 96-well plates (Corning, USA) at a density of 5 × 103 cells per well, incubated overnight, and then treated with various concentrations (0, 10, 20, 40, and 80 μmol/L) of baicalin for 24, 48, and 72 h. Thereafter, 20 μl of MTT solution (5 mg/mL; Sigma-Aldrich, St. Louis, MO, USA) was added to each well, and the plates were incubated at 37°C for 4 h. The formed formazan crystals were dissolved in 100 μl of DMSO after removal of the supernatant. The optical density (OD) was recorded at 490 nm using a microplate reader (Bio-Tek, Winooski, VT, USA). The percentage of cell viability was calculated as: (OD of baicalin-treated group/OD of control group) × 100%. |
| 浓度 | 0, 10, 20, 40, and 80 μmol/L |
| 处理时间 | 24, 48 and 72 h |
*上述方法来自公开文献，仅供相同目的实验参考。如实验目的、材料、方法不同，请参考其他文献。
| 体内实验* | |
|---|---|
| 动物模型 | Six-week old athymic nude mice bearing Hep G2 cells xenograft model |
| 配制 | 10% DMSO and 90% propylene glycol |
| 剂量 | 50 mg/kg and 100 mg/kg daily for 3 weeks |
| 给药处理 | i.p. |
验证：
参考文献：
| DMSO | 82 mg/mL (199.25 mM) |
| Ethanol | 3 mg/mL (7.29 mM) |
| Water | Insoluble |
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4299 mL | 12.1495 mL | 24.2990 mL |
| 5 mM | 0.4860 mL | 2.4299 mL | 4.8598 mL |
| 10 mM | 0.2430 mL | 1.2149 mL | 2.4299 mL |
| 50 mM | 0.0486 mL | 0.2430 mL | 0.4860 mL |
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液。
一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。（为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间)。
我们确保产品在保持试剂质量的条件下运输。收到产品后，请遵循产品数据表上的存储建议。
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