• 生物活性

靶点及简介 ：

Adenosine analog,antitumor antibiotic.

Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物，为 X 盒结合蛋白 1 (XBP1) 抑制剂，抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂，IC50 值为 80 nM。Toyocamycin (Vengicide) 诱导凋亡，对 IRE1α 的自身磷酸化没有作用。

• 验证及参考文献

验证：

参考文献：

[1] Ikuko Takahara, et al. PLoS One . Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice

[2] Ri M, et al. Blood Cancer J. Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing.

[3] Nishioka H, et al. J Antibiot (Tokyo). Inhibition of phosphatidylinositol kinase by toyocamycin.

• 溶解度及制备方案
  

  Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
  1 mM	3.4334 mL	17.1668 mL	34.3336 mL
  5 mM	0.6867 mL	3.4334 mL	6.8667 mL
  10 mM	0.3433 mL	1.7167 mL	3.4334 mL