IWP-2-V2 (CAS#877618-79-6 目录号D914546) Wnt抑制剂
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1mg | ¥ 635.00 | 100 | |
5mg | ¥ 3003.00 | 100 | |
10mg | ¥ 5640.00 | 100 | |
25mg | ¥ 11723.00 | 100 |
产品名 | IWP-2-V2 |
CAS号 | 877618-79-6 |
目录号 | D914546 |
化学式 | C₂₃H₂₀N₄O₂S |
分子量 | 480.6 |
溶解度 | ≤2mg/ml in DMSO;5mg/ml in dimethyl formamide |
靶点 | Wnt production inhibitor |
储存条件 | Store at -20°C |
用途 | 仅供科学研究使用!不能用于人体及动物治疗 |
纯度 | >98% |
靶点及简介 :
Wnt production inhibitor,Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.1,2,3Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-2 (Item No. 13951) is an inhibitor of Wnt production (IC50 = 27 nM) that inactivates porcupine, a membrane-bound O-acyltransferase whose palmitoylation activity is essential For the signaling ability and secretion of Wnt proteins.
IWP-2-V2 is a less potent IWP-2 derivative whose chemical structure retains the benzothiazole group of its parent compound. It has been used to determine which structural features of IWP-2 are essential For impairing Wnt/β-catenin pathway activity.4For the detailed information of IWP-2-V2, the solubility of IWP-2-V2 in water, the solubility of IWP-2-V2 in DMSO, the solubility of IWP-2-V2 in PBS buffer, the animal experiment (test) of IWP-2-V2, the cell expriment (test) of IWP-2-V2, the in vivo, in vitro and clinical trial test of IWP-2-V2, the EC50, IC50,and Affinity of IWP-2-V2
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