• 生物活性

靶点及简介 ：Azole antifungal agent(interdigital tinea pedis)

Luliconazole(NND 502)是一种广谱抗真菌药物。

Luliconazole(NND 502) is an azole antifungal indicated for the topical treatment of interdigital tinea pedis.IC50 Value: Target: AntifungalLuliconazole is an antifungal that belongs to the azole class. Although the exact mechanism of action against dermatophytes is unknown, luliconazole appears to inhibit ergosterol synthesis by inhibiting the enzyme lanosterol demethylase. Inhibition of this enzyme’s activity by azoles results in decreased amounts of ergosterol, a constituent of fungal cell membranes, and a corresponding accumulation of lanosterol. In a fertility study in rats, subcutaneous doses of 1, 5 and 25 mg/kg/day luliconazole were administered prior to and during mating and through early pregnancy. Treatment related effects on reproductive function were noted in females (decreased live embryos and decreased corpus luteum) at 5 and 25 mg/kg/day and males (decreased sperm counts) at 25 mg/kg/day. No treatment related effects on fertility or reproductive function were noted at 1 mg/kg/day (0.1X MRHD based on BSA comparisons).

• 验证及参考文献

验证：

参考文献：

[1] Jarratt M, et al. Cutis. Luliconazole for the treatment of interdigital tinea pedis: A double-blind, vehicle-controlled study.

[2] Koga H, et al. Antimicrob Agents Chemother. Short-term therapy with luliconazole, a novel topical antifungal imidazole, in guinea pig models of tinea corporis and tinea pedis.

[3] Koga H, et al. Med Mycol. In vitro antifungal activities of luliconazole, a new topical imidazole.

• 溶解度及制备方案
  

  DMSO	71 mg/mL  (200.41 mM)
  Ethanol	5 mg/mL  (14.11 mM)
  Water	Insoluble

制备储备液

浓度   溶剂体积    质量	1 mg	5 mg	10 mg
1 mM	2.8226 mL	14.1131 mL	28.2263 mL
5 mM	0.5645 mL	2.8226 mL	5.6453 mL
10 mM	0.2823 mL	1.4113 mL	2.8226 mL
50 mM	0.0565 mL	0.2823 mL	0.5645 mL

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  关键词：Luliconazole, NND 502, Luliconazole供应商, 购买Luliconazole, Luliconazole溶解度, Luliconazole结构式