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靶点及简介 ：A bacterial quorum-sensing signaling molecule

N-3-Hydroxydecanoyl-DL-Homoserine lactone 是一种细菌群体感应分子。N-3-Hydroxydecanoyl-DL-Homoserine lactone 通过激活识别 N-酰基同型半乳糖内酯 (AHLs) 的转录因子 SdiA (EC₅₀ 为 0.6 µM) 在沙门氏菌 (S. enterica) 中发挥作用。

N-3-hydroxydecanoyl-DL-Homoserine lactone is a bacterial quorum-sensing molecule. It activates SdiA (EC50 = 0.6 µM), a transcription factor that detects N-acyl homoserine lactones (AHLs), in the 14028/pJNS25 strain of S. enterica. 1.Fekete, A., Frommberger, M., Rothballer, M., et al.Identification of bacterial N-acylhomoserine lactones (AHLs) with a combination of ultra-performance liquid chromatography (UPLC), ultra-high-resolution mass spectrometry, and in-situ biosensorsAnal. Bioanal. Chem.387455-467(2007) 2.Janssens, J.C.A., Metzger, K., Daniels, R., et al.Synthesis of N-acyl homoserine lactone analogues reveals strong activators of SdiA, the Salmonella enterica serovar Typhimurium LuxR homologueAppl. Environ. Microb.73(2)535-544(2007)

参考文献：

[1]. Fekete A, et al. Identification of bacterial N-acylhomoserine lactones (AHLs) with a combination of ultra-performance liquid chromatography (UPLC), ultra-high-resolution mass spectrometry, and in-situ biosensors. Anal Bioanal Chem. 2007 Jan;387(2):455-67.

[2]. Janssens JC, et al. Synthesis of N-acyl homoserine lactone analogues reveals strong activators of SdiA, the Salmonella enterica serovar Typhimurium LuxR homologue. Appl Environ Microbiol. 2007 Jan;73(2):535-44.