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| 别名 | N/A |
| 产品名 | UPCDC-30245 |
| CAS号 | 1883351-01-6 |
| 目录号 | D808850 |
| 化学式 | C28H38FN5 |
| 分子量 | 463.63 |
| 溶解度 | N/A |
| 靶点 | p97 |
| 储存条件 | Store at -20°C |
| 用途 | 仅供科学研究使用!不能用于人体及动物治疗 |
| 纯度 | ＞99% |
UPCDC-30245 binds at the junction between the D1 dan D2 domains of p97[1]. UPCDC-30245 inhibits cell proliferation in HeLa, A549, BxPC-3, PRMI8226, MM1S, HCT116 cells, and appears more potent in HT29 cells[2].UPCDC-30245 (0.01-100 μM) shows anti-proliferative effects on parental and CB-5083 resistant HCT116 cell lines that harbor a new p97 double mutation (D649A/T688A)[2].UPCDC-30245 (4 μm; 2, 6, 10, 18, 24 hours; functional enrichment analysis) is not linked to pathways typically impacted by p97 inhibition, such as protein processing in the ER, UPR, and asparagine N-linked glycosylation[3].
参考文献：
[1]. Banerjee S, et al. 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. Science. 2016 Feb 19;351(6275):871-5.
[2]. Wang F, et al. Allosteric p97 Inhibitors Can Overcome Resistance to ATP-Competitive p97 Inhibitors for Potential Anticancer Therapy. ChemMedChem. 2020 Apr 20;15(8):685-694.
[3]. Wang F, et al. Temporal proteomics reveal specific cell cycle oncoprotein downregulation by p97/VCP inhibition. Cell Chem Biol. 2021 Nov 23:S2451-9456(21)00482-7.
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液。
一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。（为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间)。
我们确保产品在保持试剂质量的条件下运输。收到产品后，请遵循产品数据表上的存储建议。
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