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Cycloastragenol,CAG, TA-65, Cyclogalegigenin, Astramembrangenin,环黄芪醇（CAS#84605-18-5目录号D803894） Telomerase抑制剂\
| 剂量 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25mg | ￥ 780.00 | 100 | |
| 1g | ￥ 7800.00 | 100 |
| 别名 | CAG, TA-65, Cyclogalegigenin, Astramembrangenin,环黄芪醇 |
| 产品名 | Cycloastragenol |
| CAS号 | 84605-18-5 |
| 目录号 | D803894 |
| 化学式 | C30H50O5 |
| 分子量 | 490.72 |
| 溶解度 | DMSO 98 mg/mL (199.71 mM) |
| 靶点 | Telomerase抑制剂 |
| 储存条件 | Store at -20°C |
| 用途 | 仅供科学研究使用!不能用于人体及动物治疗 |
| 纯度 | >99.3% |
靶点及简介 ：
Cycloastragenol (CAG, TA-65, Cyclogalegigenin, Astramembrangenin) is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells.
一种类异戊二烯，发现于 Astragalus galegiformis。Cyclogalegenin 是 Cycloastragenol 的异构体。
| 分子量 | 490.72 | ||
|---|---|---|---|
| 化学式 | C30H50O5 | ||
| CAS号 | 84605-18-5 | ||
| 储存条件 (自签收日起) | 3年 | -20°C | 粉状 |
| 1年 | -80°C | 溶于溶剂 | |
体外研究
Cycloastragenol stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. It induces telomerase activity and cAMP response element binding (CREB) activation in PC12 cells and primary neurons. CAG treatment not only induces the expression of bcl2, a CREB-regulated gene, but also the expression of telomerase reverse transcriptase in primary cortical neurons[1]. Cycloastragenol rapidly passes through the Caco-2 cell monolayer by passive diffusion, once passage through the intestinal epithelium, first-pass intestinal metabolism of Cycloastragenol might occur. Cycloastragenol can undergo extensive metabolism in rat and human liver microsomes[2].
体内研究
Oral administration of cycloastragenol (CA) for 7 days attenuates depression-like behavior in experimental mice. Oral bioavailability of cycloastragenol is about 25.70% at 10 mg/kg. Cycloastragenol is excreted through bile and feces and eliminated predominantly by the kidney in rats. It also might exist an enterohepatic circulation of cycloastragenol in rats. Cycloastragenol could be metabolized widely in vivo in rat. For oral administration the mean Tmax at 10 mg/kg, 20 mg/kg, and 40 mg/kg is 2.06±0.58 h, 1.48±0.36 h, and 2.35± 1.17 h. The t1/2 is 5.23±1.55 h, 7.33±3.03 h, and 6.06± 3.42 h, respectively. The mean absorption time of CA at 10 mg/kg is 5.70± 1.62 h; the poor absorption could be caused by the low solubility. The pharmacokinetic parameters show no significant differences among the groups of 10, 20, and 40 mg/kg except for Cmax and AUC
参考文献：
| DMSO | 98 mg/mL (199.71 mM) |
| Ethanol | 49 mg/mL (99.85 mM) |
| Water | Insoluble |
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0378 mL | 10.1891 mL | 20.3782 mL |
| 5 mM | 0.4076 mL | 2.0378 mL | 4.0756 mL |
| 10 mM | 0.2038 mL | 1.0189 mL | 2.0378 mL |
| 50 mM | 0.0408 mL | 0.2038 mL | 0.4076 mL |
关键词：Cycloastragenol (Cyclogalegigenin) , Cyclogalegigenin, Cycloastragenol (Cyclogalegigenin) 供应商, 购买Cycloastragenol (Cyclogalegigenin) , Cycloastragenol (Cyclogalegigenin) 溶解度, Cycloastragenol (Cyclogalegigenin) 结构式
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一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。（为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间)。
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